Endocrine Abstracts

Kisspeptins, peptide products of the KiSS-1 gene, are pleiotropic hormones best recognized as novel regulators of puberty onset and the reproductive system. Thus, the hypothalamus expresses both KiSS-1 and its receptor, GPR54. Hypothalamic KiSS-1 is attenuated by food restriction (72 h fast),and this provides a plausible link between negative energy balance and the disruption of reproductive function. Hypothalamic KiSS-1 mRNA levels are also reduced...